Four league wins in a row have moved United closer to the top four to spark talk they can bag a Champions League qualifying place.
Spurs still harbour hopes of mounting a serious title challenge, although their record against the rest of the ‘Big Six’ remains a worry.
United have failed to win at Tottenham in their last six matches, their worst run at any other Premier League side during the same period.
However, with a 10-point gap between themselves and Spurs, they will be eager to record a victory at Wembley.
Spurs are priced at 21/20 to win the game, with United available at 12/5 and the draw on offer at 13/5.
Confirmed starting line-ups:
— Tottenham Hotspur (@SpursOfficial) January 13, 2019
🔔 Your #MUFC team to face Spurs 🔔
— Manchester United (@ManUtd) January 13, 2019