The Gunners lost their first two matches this season, but five victories in a row has fired them up the table.
Arsenal won 2-0 at home to Watford last weekend, while Fulham crashed 3-0 at Everton.
Fulham have a woeful record against Arsenal, winning just three of their last 30 meetings in all competitions.
The two sides last met back in 2013/14, with Arsenal completing the double over their London rivals.
Fulham are priced at 19/5 to win the game, with Arsenal on offer at 8/13 and the draw available at 10/3.
Confirmed starting line-ups:
— Fulham Football Club (@FulhamFC) October 7, 2018
— Arsenal FC (@Arsenal) October 7, 2018