Liverpool trio James Milner, Naby Keita and Ben Davies are set to miss the Manchester United game, having not been pictured with the squad.
The Reds have suffered from several injury problems this season, contributing to a less than impressive campaign.
Virgil van Dijk and Joe Gomez have missed most of the season due to long-term injuries, leaving Liverpool with a central defensive crisis at one point.
Ozan Kabak has also recently been injured and is set to miss the game against Manchester United.
There has now been another blow for Liverpool with news that three players have not travelled with the squad to Old Trafford.
Milner, Keita and Davies missed the game against Southampton last weekend due to injury and all three have not travelled to Manchester, according to the Liverpool Echo.
They claim that none of the trio were pictured as the Liverpool squad got off their team bus at the hotel where the club is staying.
SL View – Will injury-hit Liverpool be able to beat Manchester United?
The showdown between United and Liverpool is the most heavily anticipated game of the week, having been delayed from almost two weeks ago.
A win for the Reds could see them rise to fifth in the Premier League table, with a game in hand on fourth-placed Chelsea.
With a number of players out of action for this game, it would be a big ask for Liverpool to come away with all three points.
However, as United only played on Tuesday evening, Ole Gunnar Solskjaer may have to rotate his squad.
The Red Devils fielded a youth-oriented team against Leicester City to ensure some of their big names stay, but he is expected to pick his strongest starting XI this evening.