Unai Emery’s haven’t lost in their last 19 games in all competitions and face a United side who are struggling to find their best form.
The Red Devils head into the game on the back of a disappointing 2-2 draw at Southampton, while Arsenal will be full of confidence after beating Tottenham Hotspur 4-2.
The results left Arsenal fourth in the Premier League standings, with United eight points behind in eighth.
United did the double over the Gunners last season, winning 3-1 away from home and 2-1 at Old Trafford.
The home side are priced at 13/10 to win the game, with Arsenal on offer at 15/8 and the draw available at 5/2.
Confirmed starting line-ups:
— Manchester United (@ManUtd) December 5, 2018
🚨 Two changes from the north London derby 🚨
— Arsenal FC (@Arsenal) December 5, 2018