Dean Smith’s side have failed to win five of their last six league matches and are under pressure to win here.
However, City are an exceptional side and are firm favourites to secure all three points.
Pep Guardiola will demand a strong reaction from his players after the 2-1 defeat against Leeds United in their last outing.
The visitors have an excellent head-to-head record against Villa, defeating the Midlands club in their last six meetings.
The home side will be without the services of Trezeguet, Jack Grealish and Morgan Sanson due to injuries. Brazilian striker Wesley Moraes is still working on his match fitness, and he is unlikely to feature.
This will be a tough challenge for Villa, especially without the creativity of Grealish and Sanson. Furthermore, Trezeguet seemed in good form lately and will also be missed.
One positive for Villa will be the fact that Kevin De Bruyne and Sergio Aguero are both ruled out of the game.
Predicted Aston Villa starting line-up: Martinez, Cash, Konsa, Mings, Targett, Nakamba, Luiz, Traore, McGinn, El Ghazi, Watkins.
Smith is likely to make one change to the side that was defeated by Liverpool. 25-year-old El Ghazi is likely to replace Trezeguet in the starting line-up.