Week 18 of the 2025 NFL season carries more weight than almost any regular-season slate in recent memory, with multiple division titles, wild-card spots, and seeding positions still unresolved heading into the January 3-4 weekend. Fantasy championship lineups lock alongside real ones, and the official injury report – spanning all 16 games across Saturday and Sunday – is the most consequential document in football right now. Several playoff-contending teams are already managing significant absences at quarterback, offensive line, and skill positions.
The NFL released final injury designations for all 32 teams ahead of the Week 18 slate. The most urgent storylines involve two teams with multiple quarterbacks on the OUT list, a pair of NFC contenders managing five-deep questionable lists at key skill positions, and the Pittsburgh Steelers entering their primetime matchup as the only team in the league with zero players listed on the injury report. Here is the full breakdown, game by game.
Commanders vs. Eagles: Jayden Daniels and Marcus Mariota both OUT in Philadelphia
The 11-5 Washington Commanders arrive at Lincoln Financial Field for a 4:25 p.m. ET Sunday kickoff without their starting quarterback and his primary backup. Jayden Daniels is OUT with a left elbow injury, and Marcus Mariota is OUT with a right hand and quad injury, leaving Washington with an extremely thin signal-caller situation against a Philadelphia defense that is 6-0 at home this season. OT Laremy Tunsil is also OUT with an oblique injury, further complicating any protection scheme a third-string quarterback would need.
The 13-3 Eagles are without significant personnel of their own: TE Dallas Goedert is OUT with a knee injury, RT Lane Johnson is OUT with a foot injury, DT Jalen Carter is OUT with a hip injury, OLB Jaelan Phillips is OUT with an ankle injury, LB Nakobe Dean is OUT with a hamstring injury, and S Marcus Epps is OUT with a concussion – six players total carrying OUT designations. Not ideal for Philadelphia either, but the Commanders’ quarterback situation is the single most destabilizing injury picture of the entire Week 18 slate. Can Washington’s third option at quarterback keep this game competitive enough to lock up their seeding position?
Lions vs. Bears: Penei Sewell OUT as Detroit manages a loaded questionable list
The 14-2 Detroit Lions arrive at Soldier Field for a 4:25 p.m. ET Sunday game with five players OUT and five more QUESTIONABLE, making this the most injury-complicated situation for any legitimate Super Bowl contender in Week 18. OT Penei Sewell is OUT with an ankle injury – a brutal blow for a Lions offensive line that has anchored one of the most efficient offenses in the NFC all season. DT Alim McNeill is OUT with an abdomen injury, LB Alex Anzalone is OUT with a concussion and personal reasons, S Thomas Harper is OUT with a concussion, and OL Trystan Colon-Castillo is OUT with a wrist injury.
WR Amon-Ra St. Brown is QUESTIONABLE with a knee and ankle injury, and OT Taylor Decker is QUESTIONABLE with a shoulder, illness, and rest designation – the kind of multi-reason tag that often signals a managed absence rather than a structural injury. The 4-12 Bears are down to one OUT designation, DL Joe Tryon-Shoyinka with a concussion, but have four QUESTIONABLE players including WR Rome Odunze with a foot injury. Detroit’s depth across the offensive line will be tested heading into what could be a playoff bye-week tune-up – or an injury-aggravation nightmare.
Packers vs. Vikings: Aaron Jones and T.J. Hockenson OUT in a win-or-in scenario
The 11-5 Green Bay Packers travel to U.S. Bank Stadium with four players OUT, headlined by WR Savion Williams (foot/illness) and LB Nick Niemann (pectoral injury). WR Dontayvion Wicks is DOUBTFUL with a concussion, and QB Malik Willis is QUESTIONABLE with a right shoulder and hamstring injury – a notable designation given Green Bay may need Willis to be a functional option if Jordan Love faces any pressure situations. OL Zach Tom is also QUESTIONABLE with a back and knee issue.
The 14-2 Minnesota Vikings are without RB Aaron Jones (hip), WR Myles Price (ankle), TE Gavin Bartholomew (back), and TE T.J. Hockenson (shoulder) – all four carrying OUT designations. Hockenson’s absence is particularly significant: the former first-round tight end has been a cornerstone of Kevin O’Connell’s two-tight-end sets all season. CB Dwight McGlothern is the lone Viking listed as QUESTIONABLE. Both teams control their own destiny in the NFC North race, which makes this the most consequential divisional game of the weekend from a seeding standpoint.
Seahawks vs. 49ers: Charles Cross OUT, George Kittle and Trent Williams QUESTIONABLE
The Saturday night showcase at Levi’s Stadium – 8:00 p.m. ET on ABC and ESPN – features a Seattle offensive line already missing OT Charles Cross for the third consecutive game with the same hamstring injury. Replacement LT Josh Jones is listed as QUESTIONABLE with an ankle and knee issue after playing all 66 offensive snaps in Week 17. Seahawks coach Mike Macdonald indicated midweek that Jones was “just banged up a little bit” and expected to suit up, framing the designation as pain management rather than a structural limitation. S Coby Bryant is DOUBTFUL with a knee injury.
The San Francisco 49ers carry five QUESTIONABLE designations with no players OUT – a relatively favorable picture – but the names involved are significant: WR Ricky Pearsall (knee/ankle), TE George Kittle (ankle), OT Trent Williams (hamstring), DE Keion White (groin), and CB Upton Stout (concussion). Williams in particular has been managing his hamstring situation for multiple weeks. A fully healthy San Francisco front has the personnel to exploit a reshuffled Seattle tackle pairing, and that matchup could define how many passing lanes Geno Smith – wait, that’s the Raiders – how many lanes Seattle’s quarterbacks have to work with under pressure.
Colts vs. Texans: Anthony Richardson OUT with eye injury in Houston
Indianapolis enters NRG Stadium with Anthony Richardson OUT due to an eye injury – one of the stranger injury designations of the 2025 season – alongside TE Will Mallory (lung), CB Sauce Gardner (calf), and S Daniel Scott (knee). Richardson’s absence means Indianapolis will operate with a backup quarterback in a road environment against a Texans defense that still has teeth despite its own injury losses. The Texans, who know firsthand what a quarterback injury can cost a team mid-season after C.J. Stroud missed three consecutive games with a concussion in Week 12, have four players OUT themselves: LB Jamal Hill (calf), CB Kamari Lassiter (ankle/knee), CB Ajani Carter (hamstring), and DE Darrell Taylor (ankle).
Houston also has OT Trent Brown QUESTIONABLE with an ankle and knee issue, which adds offensive line uncertainty to both sidelines in a divisional game with AFC South implications. Not ideal for either team’s injury department heading into a game that could affect playoff seeding.
Chiefs vs. Raiders: Trey Smith and Xavier Worthy headline Kansas City’s list
The 15-1 Kansas City Chiefs arrive at Allegiant Stadium with G Trey Smith OUT (ankle) and TE Jake Briningstool OUT (hamstring). More urgently, WR Xavier Worthy is DOUBTFUL with an illness – and historically, doubtful players dress out at a rate below 10 percent league-wide, making Worthy’s availability for a team that uses him as a speed-element vertical threat a genuine game-plan variable. RB Isiah Pacheco and DE George Karlaftis are both QUESTIONABLE with rest designations, suggesting Kansas City is managing load on players it already has locked in for the postseason.
The Raiders are without QB Geno Smith (ankle), G Dylan Parham (illness), and DT Adam Butler (biceps), with RB Raheem Mostert QUESTIONABLE with a knee and ankle issue. Las Vegas has nothing to play for in the standings, making this effectively a tune-up game for Kansas City – but the Chiefs’ front office will want key contributors healthy before the playoffs begin.
Ravens vs. Steelers: Pittsburgh enters with a clean injury report
Sunday night’s AFC North finale at Acrisure Stadium – 8:20 p.m. ET on NBC and Peacock – features the Baltimore Ravens with three QUESTIONABLE designations and zero OUT players: WR Rashod Bateman (illness), DT Taven Bryan (knee), and CB Marlon Humphrey (illness). The Ravens are otherwise as healthy as any team in the league entering this matchup. The Pittsburgh Steelers are the only team in the entire NFL with zero players listed on the injury report for Week 18 – a genuinely rare occurrence at the end of a 17-game regular season.
Official inactives for all 16 games post 90 minutes before each kickoff, and late Saturday downgrades have flipped outcomes in prior Week 18 slates. With playoff seeding, division titles, and wild-card spots still live across both conferences, the cleanest injury report in football belongs to Pittsburgh – and whether that health advantage shows up in the most important regular-season game of the year in the AFC North is the question that closes the 2025 regular season.
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