The Reds have enjoyed a great start to the season so far and despite drawing their last match against Swansea at the Liberty Stadium, they still have a slender one point lead over Arsenal; so, another victory will secure their position at the top for another week, irrespective of other results.
Southampton have averaged the second-highest possession figure this season (59.1%) but have won just only once in their last 10 Premier League matches.
Jose Enrique has been replaced by Sakho while Agger has returned to the starting line-up taking the centre-back position beside Martin Skrtel
Mignolet, Toure, Sakho, Agger, Skrtel, Lucas, Henderson, Gerrard, Aspas, Moses, Sturridge.
Subs: Jones, Kelly, Sterling, Enrique, Wisdom, Ibe, Alberto
Boruc, Clyne, Fonte, Lovren, Shaw, Wanyama, Schneiderlin, Lallana (c), Rodriguez, Lambert, Osvaldo.
Subs: K. Davis (GK), S. Davis, Ramírez, Ward-Prowse, Cork, Chambers, Hooiveld
This is how Liverpool could shape up today
Let us know your thoughts about the line up and prediction?