A 1-0 victory over Bournemouth in their last match took the Gunners up to third in the table and they will be eager to keep rolling at Bramhall Lane.
The Blades have made a steady start to life in the top flight, winning two and drawing three of their first eight games.
They pushed table-topping Liverpool hard when they visited Sheffield at the end of September and could make life difficult for Arsenal.
The two sides have met on six occasions during the Premier League era, with half of those matches ending in a draw.
Arsenal are yet to win at Bramhall Lane in the Premier League, but are fancied to put that right this evening.
Confirmed starting line-ups:
Mousset & Didzy lead the line 🙌
Here's the Bladesmen starting XI 👇
— Sheffield United (@SheffieldUnited) October 21, 2019
📋 Just one change from our last @premierleague outing…
— Arsenal (@Arsenal) October 21, 2019