Home News nfl playoff picks cowboys vs 49ers odds preview prediction

NFL Playoff Picks – Wildcard Weekend: Dallas Cowboys vs San Francisco 49ers Odds, Preview, & Prediction

Author image



We sometimes use affiliate links in our content, when clicking on those we might receive a commission – at no extra cost to you. By using this website you agree to our terms and conditions and privacy policy.

8 min read

Join our Telegram channel to stay up to date on the latest in marketing

Dallas Cowboys welcome the San Francisco 49ers to the AT&T Stadium this Wildcard Weekend, and our betting expert is ready with NFL Playoff Picks for the game. Plus, find out how you can get a $1,000 deposit bonus at BetOnline in time for Sunday.  

Click here to get a $1,000 deposit bonus at BetOnline when you sign up to bet on Cowboys vs 49ers

  • NFL – Dallas Cowboys vs San Francisco 49ers
  • Sunday, January 16 at AT&T Stadium, Dallas, TX
  • The game begins at 16:30 EST
  • Broadcast live on CBS & Nickelodeon

NFC East division winners the Dallas Cowboys will host the third-placed team from the hotly contested NFC West in one of the picks of the Wildcard Round this Sunday.

For the latest odds as broadcast at BetOnline, a complete game preview, the latest injury news, and our expert’s NFL Playoff Picks for the game, read on:

Cowboys vs 49ers Odds 

Below are the latest Cowboys vs 49ers odds as seen on BetOnline on Thursday, January 13.

Our betting picks are highlighted in bold but do be aware that the odds are subject to change pending updated injury news etc. ahead of the opening punt.

Game Lines Cowboys 49ers
Moneyline -162 +142
Spread -3 (-115) +3 (-105)
Total Points U51 (-113) O51 (-107)
NFL Picks on the Prop Market: Dak Prescott to have 275+ Passing Yards and DAL to Win +127 n/a

Click here to bet on Cowboys vs 49ers at BetOnline

Cowboys vs 49ers Preview 

The Cowboys (12-5) won five of their last six games to take divisional honors in the NFC East, closing things out with a superb 51-26 victory over arch-rivals the Philadelphia Eagles.

QB Dak Prescott went 21-27, for 295-yards, five TD passes, and no interceptions in the game. It was a performance that cemented Prescott as an outside candidate for MVP honors.

After recovering from such a severe ACL injury that kept him out for most of last season, it’s been something of a Disney return to form for Prescott, who finished the year with 4,449-yards and 37 TDs.

With Prescott in such dynamic form under center, and backed up by a stern offensive line and a trio of great receivers in CeeDee Lamb (1,102-yards; 6TDs ), Amari Cooper (865-yards; 8 TDs), and -surprise package- TE Dalton Schultz (808-yards; 8 TDs), Dallas boasts the No.1 offense in the NFL for yards per game, averaging 407-YPG.

The one-two punch combo at the running back position of Ezekiel Elliot and Tony Pollard also deserves mention. The pair combined for over 1,700-yards and 12 TDs, enabling Dallas to keep things versatile and interesting on offense.

In fact, the Cowboys are a team that can hurt you in many ways. And that’s even when they don’t have the ball! The defense gave up yards but balled out all year in terms of big plays, and the 49ers will need to keep a particular eye on rookie LB Micah Parsons (13 sacks; 3 FFs) and sophomore S Trevon Diggs (11 interceptions).

Combined, the impactful pair of Parsons and Diggs was a huge reason for Dallas finishing up the regular season as the NFL’s No.1 ranked team for turnover differential (+14). Jimmy G just needs to keep the ball away from both of them!

nfl playoff picks 49ers WR RB Deebo Samuel has been one of the best players in the NFL in 2021 22
NFL Playoff Picks: 49ers WR RB Deebo Samuel has been one of the best players in the NFL in 2021 22

As always under head coach Kyle Shanahan, the 49ers have been a great team to watch thus far this year.

Shanahan’s unique play calls, particularly in the run game, managed to mesmerize enough defenses to see the 49ers go 9-8 and eke into the playoffs after that fine comeback win in overtime vs the Rams on the final day. Sure, it was a performance that eliminated my Saints. But few could argue that San Francisco deserved it after recovering from a 17-point deficit in the first quarter, not to mention going 7-2 down the stretch, and in a tough division to boot!

After all the hysteria at the Draft when San Francisco moved up to select Trey Lance, veteran QB, Jimmy Garoppolo managed to retain the jersey in Lance’s rookie year. Jimmy G played efficient football, finishing up with 3,810-yards and 20 TDs.

But, if I were a 49ers fan, I would be slightly concerned about Garoppolo’s 12 picks. Especially with the former Pat now going up against Trevon Diggs in the Cowboys’ secondary. On that note, with Micah Parsons likely to be bringing it all day as per usual, it’s hugely important that the 49ers’ offensive line holds up. It’s hard to imagine things going well for San Fran if Jimmy G is constantly throwing under pressure.

If Trent Williams is passed fit to play, and the 49ers OL does hold up, expect to see a big afternoon for arguably the league’s most exciting offensive threat this year – the indomitable Deebo Samuel.

Samuel finished up the year with an incredible 1,770-yards from scrimmage and 14 TDs. In seasons gone by, this would be enough to see him in with a good shot at winning MVP.

If San Francisco can consistently get the ball to Deebo, bruising sophomore WR Brandon Aiyuk, and even more terrifying TE George Kittle, it will be a long afternoon’s work for the Cowboys linebackers and secondary, and you’d have to give Shanahan’s 7th-ranked NFL offense (375-YPG) a chance at the W.

And that’s especially because, on defense, the 49ers have been highly efficient all year. And that’s without the now-Jets head coach Robert Saleh at the helm.

Fred Warner commands the D and sets the example. His superior reading of the game enabled him to make an astonishing 137 tackles during the regular season. And, of course, Cowboys QB Dak Prescott will need to stay aware of the oncoming threats of Nick Bosa (15.5 sacks; 4 FFs) and Arik Armstead. Combined, this fit-and-firing 49ers’ D ranked 3rd in the NFL for YAPG in 2021/22, ceding just 310-yards per game on average.

Click the link to find out more about the best NFL sportsbooks.

Cowboys vs 49ers Team News

cowboys vs 49ers picks 49ers OT Trent Williams is an injury concern for coach Kyle Shanahan
Cowboys vs 49ers picks: 49ers OT Trent Williams is an injury concern for coach Kyle Shanahan

Dallas coach Mike McCarthy will be pleased to note that his team has no new injury worries on offense. The former Packers boss will now be crossing his fingers and toes that things stay that way until Sunday.

On defense, LB Keanu Neal (chest/elbow) is a slight concern but is expected to suit up.

For the 49ers, things are certainly going better than they went last year with regards to injuries. But, with Dallas on the horizon, head coach Kyle Shanahan will be hoping RB Elijah Mitchell (knee) is ready to go. Mitchell was a light participant in Thursday’s practice. And, ahead of Mitchell, there are concerns over one of the NFL’s best offensive linemen, too. Trent Williams has an elbow problem. However, in a conversation with ESPN, Shanahan indicated that the big man was ‘doing everything he could to get himself ready for Sunday.

For the 49ers’ defense, LB Azeez Al-Shaair is a concern. But, the bigger problems lay at safety. Both Jaquiski Tartt and Talanoa Hufanga are nursing injuries, potentially leaving the 49ers short in coverage options.

Cowboys vs 49ers Wildcard Round Picks

This is such a tough game to call. The 49ers and the Cowboys play totally different brands of football but both teams have stars who can get you a W… and on both sides of the ball, too.

At 12-5, the Cowboys have the superior record, but few would argue that the 49ers had to battle the tougher schedule – three teams from San Fran’s division made it into the playoffs this year, after all.

Because they’ve got the home-field advantage, we’re backing Dallas on the spread at -3. But, to be honest, this one really could go either way. It’s largely just going to come down to which team turns up and balls out on the afternoon.


Cowboys vs 49ers Prediction: Dallas to win and cover the -3 spread (-115) is our NFL Wildcard Round Pick for the weekend.

Click here to bet on Dallas to win and cover the -3 spread (-115)  at BetOnline

NFL Wildcard Round Free Bets for 49ers at Cowboys

Chargers vs Chiefs NFL Predictions - Free Bet at BetOnline
Wildcard Weekend Free Bets at BetOnline

By signing up at BetOnline ahead of the NFC Playoff clash: 49ers @ Cowboys this Sunday, newcomers are entitled to receive up to $1,000 in NFL free bets.

There are many other offers available at the sportsbook too, most of which can be viewed by clicking on the following BetOnline promo codes link.

For the $1,000 welcome bonus, however, see below:

  1. Click the link to go to BetOnline
  2. Register a new account using promo code BOL1000
  3. Deposit between $10 – $1,000
  4. BetOnline matches your first deposit by 50% up to the value of $1,000

Get a $1,000 Deposit Bonus at BetOnline

Join our Telegram channel to stay up to date on the latest in marketing