The two sides are locked together at the top of the table, with both winning six and drawing one of their seven matches this season.
The Reds were held 1-1 by Chelsea last weekend, while City won 2-0 against Brighton & Hove Albion.
Liverpool were beaten 5-0 by City at the Etihad Stadium back in September, but they gained their revenge with a 4-3 home success later in the season.
They also triumphed 5-1 on aggregate when the two sides met in the quarter-finals of the Champions League.
Liverpool are priced at 7/5 to win the game, with City on offer at 7/4 and the draw available at 13/5.
Confirmed starting line-ups:
#LIVMCI team news time! ?
— Liverpool FC (@LFC) October 7, 2018
The Boys in Blue! ?
CITY XI | Ederson, Walker, Stones, Laporte, Mendy, Fernandinho, Silva (C), Bernardo, Mahrez, Sterling, Aguero
SUBS | Muric, Danilo, Kompany, Sané, Otamendi, Jesus, Foden
— Manchester City (@ManCity) October 7, 2018