Samuel was understood to have been on his way home from dropping his kids off at school when he collided with a van.
Police and an air ambulance were sent to the scene after Samuel’s Range Rover burst into flames following the incident.
Samuel was best known for his spells with Villa and Bolton whom he represented in the Premier League. He made more than 169 appearances for Villa during a nine-year spell between 1998-2007 and also made more than 71 appearances for Bolton between 2007-2011.
Samuel represented England at youth level but switched allegiance to the nation of his birth, Trinadad and Tobago at senior international level. He won two caps for the twin island republic.
He is survived by his wife Emma, with whom he had three children- Javarne,10,Lakyle,8 and Amara,5.
A statement released by Chesire Police said:
“Emergency services remain at the scene of a serious collision involving a van and a car in High Legh.
“Sadly the driver of the car, Jlloyd Samuel, 37, from Lymm, died at the scene.
“His next of kin have been informed and are currently being supported by specially trained officers.
“The driver of the van, a 54-year-old man, sustained serious injuries and has been taken to hospital for treatment.
“Road closures remain in place at either end of West Lane, near to the junctions of the A56 and the A50. Motorists are advised to avoid the area.”