The Blues head into the game fourth in the table, four points behind third-placed Tottenham Hotspur.
They were disappointing in their last home league match, labouring to a goalless draw with Southampton.
Newcastle remain in relegation trouble after winning just four times this season.
Chelsea have lost just one of their last seven meetings with Newcastle in all competitions and are strongly fancied to pick up three points this weekend.
The home side are priced at 1/4 to win the game, with Newcastle on offer at 11/1 and the draw available at 9/2.
Confirmed starting line-ups:
— Chelsea FC (@ChelseaFC) January 12, 2019
— Newcastle United FC (@NUFC) January 12, 2019