The Israeli defender limped off with seven minutes to play in Rome after failing to shake off the knock, and he has since undergone a scan.
Celtic boss Neil Lennon disclosed the extent of Elhamed’s injury is unknown, but it seems the full-back is set to spend some time on the sidelines after his latest post on Instagram.
The 28-year-old wrote on his Instagram story on Saturday: “Bad news this morning but I will be back stronger.
“Thank God always.”
It will come as a huge blow to Celtic given how impressive Elhamed has been since his £1.6million arrival from Hapoel Be’er Sheva in the summer.
The 28-year-old has since played 13 games for the Hoops, particularly putting in an impressive shift in the 2-0 win over Rangers at Ibrox in September.
Elhamed now has to prove his fitness ahead of the clash, but Lennon has a quality cover in Jeremie Frimpong who has been impressive since making his debut, while Moritz Bauer and Nir Bitton are also options in the position.