The Gunners were beaten 3-1 at Liverpool, while Spurs slipped to a disappointing home reverse against Newcastle United.
Hector Bellerin, Konstantinos Mavropanos and Kieran Tierney remain on the sidelines for the home side, but Mesut Ozil should return.
Alexandre Lacazette should come back into the starting XI after impressing as a substitute at Anfield.
Tanguy Ndombele and Kyle Walker-Peters are both doubtful for Spurs, while Ryan Sessegnon and Juan Foyth are definitely out.
Dele Alli could return after a thigh injury in place of Erik Lamela.
Predicted starting line-ups:
Arsenal: Leno, Maitland-Niles, Sokratis, David Luiz, Monreal, Xhaka, Ceballos, Guendouzi, Pepe, Lacazette, Aubameyang.
Spurs: Lloris, Walker-Peters, Alderweireld, Vertonghen, Rose, Sissoko, Winks, Alli, Eriksen, Kane, Son.