The Hammers are currently 15th in the table, six points above the relegation zone with six games to play.
Stoke are deep in trouble, six points adrift of safety but with only five matches remaining.
West Ham have won one and drawn five of their last seven meetings with Stoke, but they haven’t beaten them at home since 2011.
Mark Noble, Marko Arnautovic and Diafra Sakho got the goals for the Hammers in their 3-0 victory at Stoke back in December.
West Ham are priced at 19/20 to win the game, with Stoke on offer at 16/5 and the draw available at 5/2.
Confirmed starting line-ups:
— West Ham United (@WestHamUtd) April 16, 2018
— Stoke City FC (@stokecity) April 16, 2018