City were held to a 1-1 draw by Burnley last weekend and manager Pep Guardiola has numerous injury problems to contend with against the Foxes.
Fabian Delph, Phil Foden, Gabriel Jesus, Leroy Sane and Benjamin Mendy have all been ruled out of the game.
Leicester have named wantaway winger Riyad Mahrez amongst their substitutes despite him not turning up to training during the week.
City are priced at 2/9 to win the game, with Leicester on offer at 12/1. The draw is available at 6/1.
Guardiola’s side won 2-0 at the King Power Stadium earlier in the season and are strongly fancied to complete the double this evening.
Confirmed starting line-ups:
How we line-up against the Foxes! #cityvlcfc
City XI | Ederson, Walker, Laporte, Otamendi, Zinchenko, Fernandinho (C), Gündogan, De Bruyne, Sterling, Bernardo, Agüero
Subs | Bravo, Danilo, Kompany, Stones, Nmecha, Foden, Diaz
— Manchester City (@ManCity) February 10, 2018
Today's starting XI: Schmeichel (c), Dragović, Maguire, Fuchs, Albrighton, Silva, Ndidi, James, Chilwell, Diabaté, Vardy.
— Leicester City (@LCFC) February 10, 2018