The Premier League giants are plagued with injuries and could be missing up to twelve first-team players for the clash against Watford today.
The likes of Young, Smalling, Rooney, Martial, Januzaj, Shaw, Fellaini, Jones and Schweinsteiger are set to miss the game and Van Gaal will have to settle for several youth players.
Young full back Borthwick-Jackson is also a doubt for the game and will be assessed closer to the kickoff. Marcus Rashford is expected to start once again after scoring four goals in his last two appearances against Midtjylland and Arsenal.
Guillermo Varela or Timothy Fosu-Mensah are expected to fill in as the full backs.
Star striker Anthony Martial is back after missing their last two matches with a hamstring injury and should be on the bench for this game.
Academy graduates including Joe Rothwell, James Weir, Regan Poole and Joe Riley are also in the match day squad.
Predicted Manchester United Lineup against Watford:
De Gea; Varela, Darmian, Rojo, Blind; Schneiderlin, Herrera; Depay, Mata, Lingard; Rashford
Predicted Score: Manchester United 2-1 Watford