Liverpool currently lead the way in the league with 74 points, but City are right behind them on 70, crucially with two games in hand.
A win for either side will huge in terms of the title race, while third challenger Chelsea will be hoping for a draw.
Read more – Liverpool vs Manchester: The Big Preview
Here are the confirmed Liverpool vs Manchester City lineups:
Liverpool: Mignolet, Johnson, Flanagan, Sakho, Skrtel, Gerrard, Henderson, Coutinho, Sterling, Suarez, Sturridge
Subs: Jones, Toure, Agger, Aspas, Moses, Allen, Lucas
Manchester City: Hart, Zabaleta, Kompany, Demichelis, Clichy, Toure, Fernandinho, Navas, Nasri, Silva, Dzeko
Subs: Pantilimon, Lescott, Kolarov, Javi Garcia, Milner, Negredo, Aguero
What do you think? Who will come out on top? Let me know in the comments below…